Description

Benzaldehyde-Peg4-Azide CAS NO 1151451-77-2 is a specialized bifunctional linker molecule featuring a benzaldehyde group and a terminal azide, connected by a tetraethylene glycol (PEG4) spacer. This compound is essential for creating stable, site-specific bioconjugates via orthogonal click chemistry and aldehyde-based coupling strategies. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced materials science, enabling the precise modification of proteins, peptides, and surfaces.

Application

• Bioconjugation and Protein Labeling: Site-specific modification of antibodies, enzymes, and other proteins via oxime or hydrazone ligation with the benzaldehyde group.
• Click Chemistry Synthesis: Utilizes the terminal azide for copper-catalyzed (CuAAC) or strain-promoted (SPAAC) azide-alkyne cycloaddition to attach payloads like dyes, drugs, or polymers.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key building block for constructing cleavable or non-cleavable linkers in targeted cancer therapeutics.
• Surface Functionalization: Modification of nanoparticles, biosensors, and microarray slides to introduce bio-orthogonal handles for subsequent immobilization.
• Polymer and Dendrimer Chemistry: Introduction of reactive aldehyde and azide functionalities into polymer backbones for creating smart, cross-linkable materials.
• Chemical Biology Probes: Synthesis of activity-based probes for studying enzyme function and protein-protein interactions in live cells.

Basic Information

Product Name	Benzaldehyde-Peg4-Azide
CAS No.	1151451-77-2
Molecular Formula	C19H27N3O6
Molecular Weight	393.44 g/mol
Synonyms	4-Azido-PEG4-Benzaldehyde; Benzaldehyde-PEG4-N3; 4-Formylbenzyl-PEG4-azide; 1-Azido-3,6,9,12-tetraoxapentadecan-15-yl 4-formylbenzoate; Azido-PEG4-Benzaldehyde; PEG4-Azide-Benzaldehyde; 15-Azido-4,7,10,13-tetraoxapentadecyl 4-formylbenzoate; Benzylaldehyde-PEG4-N3
EINECS	Contact for details

Quality Control

Our Benzaldehyde-Peg4-Azide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and functional integrity. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and MS analysis. We support development and cGMP-grade manufacturing to meet the stringent requirements of preclinical and clinical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. Store away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.