Description

3-Bromo-2-Fluoropyridine-4-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated and halogenated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to construct complex pyridine-based scaffolds for novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the bromo-fluoro substitution pattern.
• Material Science Research: Serves as a building block for creating functionalized organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to introduce the 3-bromo-2-fluoro-4-pyridyl moiety into more complex molecular architectures.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Scale-Up Process Chemistry: Supplied for route scouting and optimization in kilo-lab and pilot plant environments to ensure robust and scalable synthetic pathways.

Basic Information

Product Name	3-Bromo-2-Fluoropyridine-4-Boronic Acid Pinacol Ester
CAS No.	1150561-78-6
Molecular Formula	C11H14BBrFNO2
Molecular Weight	300.95 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(3-bromo-2-fluoropyridin-4-yl)-1,3,2-dioxaborolane; 2-(3-Bromo-2-fluoro-4-pyridinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (3-Bromo-2-fluoropyridin-4-yl)boronic acid pinacol ester; 3-Bromo-2-fluoro-4-pyridineboronic acid pinacol ester; Boronic acid, B-(3-bromo-2-fluoro-4-pyridinyl)-, 1,1-dimethylethyl ester; CAS 1150561-78-6
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluoropyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for every shipment, supporting cGMP and ISO standards for traceability and reliability in critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (argon or nitrogen) when not in use to maintain product integrity and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.