Description

2-Acetamidopyridine-5-Boronic Acid,Pinacol Ester,Hcl is a high-value, protected boronic acid derivative used as a key synthetic intermediate in modern organic chemistry. This compound matters for its role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. It is primarily needed by pharmaceutical and agrochemical R&D laboratories for the development of novel active ingredients, as well as by fine chemical manufacturers producing advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex pyridine-based heterocycles.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides that require specific biaryl linkages.
• Material Science: Employed in the creation of organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Cross-Coupling Reactions: Serves as a versatile boronate ester reagent in palladium-catalyzed Suzuki-Miyaura couplings for carbon-carbon bond formation.
• Chemical Biology Probes: Useful in the synthesis of molecular probes and inhibitors for target identification and validation in drug discovery.
• Library Synthesis: A valuable reagent for medicinal chemistry teams engaged in parallel and combinatorial synthesis to generate diverse compound libraries.

Basic Information

Product Name	2-Acetamidopyridine-5-Boronic Acid,Pinacol Ester,Hcl
CAS No.	1150561-64-0
Molecular Formula	C13H19BN2O3 • HCl
Molecular Weight	297.57 g/mol (Free base: 262.11 g/mol)
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-acetamidopyridine Hydrochloride; 2-Acetamido-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Hydrochloride; N-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetamide Hydrochloride; 2-Acetamido-5-pyridineboronic Acid Pinacol Ester Hydrochloride; 2-Acetamidopyridin-5-ylboronic Acid Pinacol Ester Hydrochloride; CAS 1150561-64-0
EINECS	Contact for details

Quality Control

Our 2-Acetamidopyridine-5-Boronic Acid,Pinacol Ester,Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.