Description

5-Amino-6-Iodo-Pyridine-2-Carbonitrile is a high-value, multi-functional heterocyclic building block characterized by its reactive amino, cyano, and iodo substituents. This compound matters for its versatility in facilitating complex molecular construction, enabling efficient synthesis of advanced pharmaceutical intermediates and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, antiviral agents, and other small molecule therapeutics, leveraging its halogen and nitrile groups for cross-coupling and cyclization reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where its pyridine core provides essential bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the construction of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized to develop molecular probes and tags for studying biological processes, where the iodo group allows for further functionalization via click chemistry.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Details
Product Name	5-Amino-6-Iodo-Pyridine-2-Carbonitrile
CAS No.	1150542-25-8
Molecular Formula	C6H4IN3
Molecular Weight	245.02 g/mol
Synonyms	5-Amino-6-iodopyridine-2-carbonitrile; 6-Iodo-5-aminopicolinonitrile; 2-Cyano-5-amino-6-iodopyridine; 5-Amino-6-iodo-2-cyanopyridine; 6-Iodo-5-aminopyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 5-amino-6-iodo-; 5-Amino-6-iodo-2-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 5-Amino-6-Iodo-Pyridine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.