Description

3-(4-Methoxybenzyloxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridinehydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies for the synthesis of complex, biologically active molecules, including potential kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for oncology and CNS drug candidates.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for constructing biaryl and heterobiaryl scaffolds essential in medicinal chemistry.
• Chemical Biology & Proteomics: Used in the development of chemical probes and affinity ligands for target identification and validation studies.
• Agrochemical Research: Employed in the discovery and development of new crop protection agents with complex heterocyclic structures.
• Material Science: Potential precursor for creating organic electronic materials and metal-organic frameworks (MOFs) with specific functional properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development programs.

Basic Information

Item	Detail
Product Name	3-(4-Methoxybenzyloxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridinehydrochloride
CAS No.	1150271-39-8
Molecular Formula	C20H27BClNO4
Molecular Weight	391.70 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-[(4-methoxyphenyl)methoxy]pyridine hydrochloride; 3-[(4-Methoxybenzyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine HCl; 3-(p-Methoxybenzyloxy)-5-(pinacolboronato)pyridine hydrochloride; 1150271-39-8; 3-(4-Methoxybenzyloxy)-5-(pinacolboronato)pyridine HCl; 5-(Pinacolboronato)-3-(4-methoxybenzyloxy)pyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(4-Methoxybenzyloxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridinehydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing batch-specific results. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container for extended periods to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.