Description

3-Chloro-2-Fluoro-4-(Hydroxymethyl)Pyridine is a high-value, multi-functional heterocyclic building block with significant synthetic utility. This compound is prized for its unique halogenated pyridine core, which serves as a versatile intermediate in the construction of complex molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for use in medicinal chemistry, process development, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated pyridine derivatives.

Basic Information

Product Name	3-Chloro-2-Fluoro-4-(Hydroxymethyl)Pyridine
CAS No.	1149587-00-7
Molecular Formula	C6H5ClFNO
Molecular Weight	161.56 g/mol
Synonyms	4-(Hydroxymethyl)-3-chloro-2-fluoropyridine; 2-Fluoro-3-chloro-4-pyridinemethanol; 3-Chloro-2-fluoro-4-pyridinemethanol; (3-Chloro-2-fluoro-4-pyridinyl)methanol; 2-Fluoro-3-chloro-4-(hydroxymethyl)pyridine
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Fluoro-4-(Hydroxymethyl)Pyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.