Description

Spiro[Cyclohexane-1,3'-[3H]Indole]-4-Carboxylic Acid, 1',2'-Dihydro-1'-(Methylsulfonyl)-, Methyl Ester, trans- is a sophisticated spirocyclic indole derivative, a high-value synthetic intermediate prized for its unique three-dimensional molecular architecture. This compound is critical for medicinal chemistry research and development, enabling the exploration of novel bioactive molecules. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of complex heterocyclic compounds for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new chemical entities with optimized biological activity and pharmacokinetic profiles.
• Spirocyclic Compound Library Synthesis: Serves as a core scaffold for creating diverse compound libraries for high-throughput screening in drug discovery.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of advanced pharmaceutical intermediates.
• Academic Research: Utilized in universities and research institutes for studying synthetic methodologies and the properties of complex spiro-fused ring systems.

Basic Information

Product Name	Spiro[Cyclohexane-1,3'-[3H]Indole]-4-Carboxylic Acid, 1',2'-Dihydro-1'-(Methylsulfonyl)-, Methyl Ester, trans-
CAS No.	1148009-65-7
Molecular Formula	C16H19NO4S
Molecular Weight	321.39 g/mol
Synonyms	trans-Methyl 1',2'-dihydro-1'-(methylsulfonyl)spiro[cyclohexane-1,3'-indole]-4-carboxylate; (trans)-Methyl 1'-(Methanesulfonyl)-1',2'-dihydrospiro[cyclohexane-1,3'-indole]-4-carboxylate; 1',2'-Dihydro-1'-(methylsulfonyl)spiro[cyclohexane-1,3'-[3H]indole]-4-carboxylic acid methyl ester, trans-; Spiro[cyclohexane-1,3'-indole]-4-carboxylic acid, 1',2'-dihydro-1'-(methylsulfonyl)-, methyl ester, (3'R,4S)-rel-; CAS 1148009-65-7
EINECS	Contact for details

Quality Control

Our Spiro[Cyclohexane-1,3'-[3H]Indole]-4-Carboxylic Acid, 1',2'-Dihydro-1'-(Methylsulfonyl)-, Methyl Ester, trans- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent chemical identity, meeting the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and spectroscopic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound may be sensitive to prolonged exposure to moisture and should be handled under inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.