Description

tert-Butyl 6-Hydroxy-2-Azaspiro[3.3]Heptane-2-Carboxylate is a high-value, protected spirocyclic amino alcohol derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its unique spiro[3.3]heptane scaffold and orthogonal protecting groups make it indispensable for constructing complex molecular architectures with precise stereochemistry. This compound is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel small molecule therapeutics, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides with novel modes of action.
• Chiral Ligand & Catalyst Precursor: The spirocyclic structure serves as a precursor for sophisticated chiral auxiliaries and organocatalysts used in asymmetric synthesis.
• Peptidomimetics & Bioisosteres: The 2-azaspiro[3.3]heptane core is a valuable rigid scaffold for designing peptide mimics and bioisosteric replacements in medicinal chemistry.
• Material Science Research: Potential monomer or additive for creating specialty polymers with unique thermal or mechanical properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	tert-Butyl 6-Hydroxy-2-Azaspiro[3.3]Heptane-2-Carboxylate
CAS No.	1147557-97-8
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-ol; 6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; Boc-2-azaspiro[3.3]heptan-6-ol; tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate; 2-Azaspiro[3.3]heptane-6-ol, 2-(1,1-dimethylethoxy)carbonyl]-; 1147557-97-8; Boc-protected 2-azaspiro[3.3]heptan-6-ol
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Hydroxy-2-Azaspiro[3.3]Heptane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP standards where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.