Description

(2-Bromo-6-Nitrobenzyloxy)(tert-Butyl)Dimethylsilane is a high-value, protected benzyl alcohol derivative designed for advanced synthetic chemistry. This compound matters as a critical building block, offering a reactive bromo-nitro aromatic handle while the tert-butyldimethylsilyl (TBDMS) group provides orthogonal protection for the alcohol functionality. Pharmaceutical, agrochemical, and advanced materials researchers need it for constructing complex molecules, particularly in multi-step synthesis where selective deprotection and functionalization are required.

Application

• Pharmaceutical Intermediate: Key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially those containing substituted benzyl motifs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require nitroaromatic and halogenated intermediates.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Building block for organic electronic materials, such as OLEDs and conductive polymers, where its structure can be incorporated into larger conjugated systems.
• Chemical Biology & Proteomics: Useful in the synthesis of activity-based probes and affinity tags for studying enzyme function.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions like Suzuki, Heck, and Sonogashira.

Basic Information

Item	Details
Product Name	(2-Bromo-6-Nitrobenzyloxy)(tert-Butyl)Dimethylsilane
CAS No.	1147531-02-9
Molecular Formula	C13H20BrNO3Si
Molecular Weight	346.30 g/mol
Synonyms	2-Bromo-6-nitrobenzyloxy-tert-butyldimethylsilane; 1-[(tert-Butyldimethylsilyl)oxy]methyl-2-bromo-6-nitrobenzene; TBDMS ether of 2-bromo-6-nitrobenzyl alcohol; (2-Bromo-6-nitrobenzyl) tert-butyldimethylsilyl ether; tert-Butyl((2-bromo-6-nitrobenzyl)oxy)dimethylsilane; 2-Bromo-6-nitrobenzyl O-(tert-butyldimethylsilyl) ether; Silane, [(2-bromo-6-nitrophenyl)methoxy](1,1-dimethylethyl)dimethyl-
EINECS	Contact for details

Quality Control

Our (2-Bromo-6-Nitrobenzyloxy)(tert-Butyl)Dimethylsilane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and GC-MS, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.