Description

1H-Pyrazole-1-Acetic Acid, 4-Borono-, 1-Methyl Ester is a specialized boronic acid ester derivative, a key building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group with a reactive pyrazole-acetic acid ester scaffold, enabling precise cross-coupling and derivatization reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients, as well as in advanced materials science for creating functional polymers and ligands.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to construct complex heterocyclic structures found in next-generation herbicides, fungicides, and insecticides.
• Material Science & Ligand Design: Serves as a versatile monomer or ligand precursor for metal-organic frameworks (MOFs), catalysts, and functional polymers.
• Chemical Biology & Proteomics: Employed as a tool compound or probe for studying enzyme inhibition and protein-ligand interactions due to its boronate affinity.
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and catalysis research within university and CRO laboratories.

Basic Information

Product Name	1H-Pyrazole-1-Acetic Acid, 4-Borono-, 1-Methyl Ester
CAS No.	1146614-50-7
Molecular Formula	C7H9BN2O4
Molecular Weight	196.97 g/mol
Synonyms	4-Borono-1H-pyrazole-1-acetic acid methyl ester; Methyl 4-borono-1H-pyrazole-1-acetate; 1-Methyl 4-boronopyrazole-1-acetate; (1-Methoxycarbonylmethyl-1H-pyrazol-4-yl)boronic acid; 4-Boronopyrazole-1-acetic acid methyl ester; Pyrazole-1-acetic acid, 4-borono-, methyl ester; CAS 1146614-50-7
EINECS	Contact for details

Quality Control

Every batch of 1H-Pyrazole-1-Acetic Acid, 4-Borono-, 1-Methyl Ester is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity data, NMR confirmation, and residual solvent analysis to ensure reproducible performance in sensitive synthetic applications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.