Description

4-(8-Methoxy-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-4-oxobutanoic acid is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic indole structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents targeting the central nervous system. It is primarily sought by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of innovative drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly those with indole-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic targets.
• Neurological Drug Development: Serves as a precursor in the research of compounds targeting serotonin and other neurotransmitter receptors.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	4-(8-Methoxy-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-4-oxobutanoic acid
CAS No.	1146291-12-4
Molecular Formula	C₁₈H₂₀N₂O₄
Molecular Weight	328.36 g/mol
Synonyms	4-(8-Methoxy-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-4-oxobutanoic Acid; 4-Oxo-4-[8-methoxy-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]butanoic Acid; 2-(3-Carboxypropionyl)-8-methoxy-1,2,3,4,5,6-hexahydropyrido[4,3-b]indole; 8-Methoxy-2-(3-carboxypropionyl)-1,2,3,4,5,6-hexahydropyrido[4,3-b]indole; Butanedioic acid, 2-(8-methoxy-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-, (S)-; CAS 1146291-12-4
EINECS	Contact for details

Quality Control

Our production of 4-(8-Methoxy-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-4-oxobutanoic acid adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity. The material is characterized and released according to comprehensive in-house specifications, which typically include identity confirmation by spectroscopic methods, purity assessment by HPLC, and control of specific impurities. Certificates of Analysis (COA) detailing all test results are provided with each shipment. We support customer audits and can tailor quality specifications to meet the requirements of cGMP and other regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere protection.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.