Description

1H-Pyrrolo[2,3-B]Pyridine-3-Carbonitrile, 1-(1,1-Dimethylethyl)-6-Methyl-4-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its complex molecular architecture, featuring a pyrrolopyridine core with nitrile and trifluoromethyl substituents, makes it a critical intermediate for constructing novel pharmacophores. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries who require sophisticated scaffolds for drug discovery and crop protection agent development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrrolopyridine scaffold.
• Material Science: Acts as a precursor for organic electronic materials and specialty polymers where its conjugated system and functional groups are advantageous.
• Chemical Biology: Employed as a molecular probe or tag in biochemical research due to its unique structural and potential fluorescent properties.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic routes requiring complex heterocycles.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Carbonitrile, 1-(1,1-Dimethylethyl)-6-Methyl-4-(Trifluoromethyl)-
CAS No.	1146221-74-0
Molecular Formula	C14H14F3N3
Molecular Weight	281.28 g/mol
Synonyms	1-(tert-Butyl)-6-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile; 1-tert-Butyl-6-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile; 4-(Trifluoromethyl)-1-(1,1-dimethylethyl)-6-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile; tert-Butyl 6-methyl-4-(trifluoromethyl)-3-cyano-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (related protected form); Pyrrolo[2,3-b]pyridine-3-carbonitrile derivative
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-3-Carbonitrile, 1-(1,1-Dimethylethyl)-6-Methyl-4-(Trifluoromethyl)- adheres to a stringent quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.