Description

1-Methyl-5-Pivalamido-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid CAS NO 1146215-23-7 is a high-purity, advanced pharmaceutical intermediate featuring a complex pyrrolopyridine core structure. This compound is valued for its role as a critical building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of small-molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for investigational new drugs.
• Oncology Drug Discovery: Serves as a core scaffold for developing kinase inhibitors and other targeted cancer therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in R&D laboratories.
• Process Chemistry Development: Employed in scaling up synthetic routes from milligram to kilogram scale for clinical trial material production.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of drug substances.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development.

Basic Information

Item	Details
Product Name	1-Methyl-5-Pivalamido-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid
CAS No.	1146215-23-7
Molecular Formula	C15H17N3O3
Molecular Weight	287.32 g/mol
Synonyms	5-(Pivalamido)-1-methyl-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 1-Methyl-5-(2,2-dimethylpropanamido)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; 1-Methyl-5-pivalamido-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid; UNII-8K1I4F9K3R; 8K1I4F9K3R; 1146215-23-7; Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-[(2,2-dimethyl-1-oxopropyl)amino]-1-methyl-
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-Pivalamido-1H-Pyrrolo[2,3-B]Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.