Description

5-(Azetidin-3-Yloxy)-2-Bromopyridine is a high-value brominated pyridine derivative featuring an azetidine ether linkage, making it a versatile and critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating complex, nitrogen-containing heterocycles for therapeutic applications.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic programs.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization due to its reactive bromine atom and constrained azetidine ring.
• Cross-Coupling Reactions: The bromopyridine moiety is an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig cross-coupling reactions to form biaryl and C-N bond linkages.
• Ligand Synthesis: Employed in the development of novel ligands for catalysis and molecular recognition applications.
• Agrochemical Research: Used as a building block in the research and development of new crop protection agents and pesticides.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	5-(Azetidin-3-Yloxy)-2-Bromopyridine
CAS No.	1146089-82-8
Molecular Formula	C8H9BrN2O
Molecular Weight	229.08 g/mol
Synonyms	2-Bromo-5-(azetidin-3-yloxy)pyridine; 5-(Azetidin-3-yloxy)-2-bromopyridine; 2-Bromopyridin-5-yl azetidin-3-yl ether; Azetidin-3-ol, 1-(2-bromo-5-pyridinyl)oxy]-; 1146089-82-8; 5-(Azetidin-3-yloxy)-2-bromo-pyridine
EINECS	Contact for details

Quality Control

Our 5-(Azetidin-3-Yloxy)-2-Bromopyridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended long-term storage at 2-8°C. The compound is light-sensitive and should be handled under inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.