Description

4-[1-(5-Nitro-Pyridin-2-Yl)-1H-Benzoimidazol-2-Yl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity (98+%) advanced pharmaceutical intermediate with the molecular formula C21H24N6O4 and a molecular weight of 424.46. This compound is a critical building block in modern medicinal chemistry, valued for its complex heterocyclic structure that incorporates a piperazine ring, a benzimidazole core, and a nitro-substituted pyridine. It is primarily sought after by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncological pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially in oncology and neurology research.
• Protease Inhibitor Development: Used in the research and development of protease inhibitors due to the benzimidazole-piperazine scaffold.
• Kinase Inhibitor Synthesis: Serves as a core structural component in the creation of potential kinase inhibitors for targeted cancer therapies.
• Chemical Biology Research: Employed as a molecular probe or building block in chemical biology to study protein-ligand interactions and enzyme function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Academic & Institutional Research: Used in university and institutional laboratories for fundamental research in heterocyclic chemistry and medicinal chemistry.

Basic Information

Product Name	4-[1-(5-Nitro-Pyridin-2-Yl)-1H-Benzoimidazol-2-Yl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1146080-59-2
Molecular Formula	C21H24N6O4
Molecular Weight	424.46 g/mol
Synonyms	tert-Butyl 4-[1-(5-nitropyridin-2-yl)-1H-benzimidazol-2-yl]piperazine-1-carboxylate; 1-Boc-4-[1-(5-nitropyridin-2-yl)-1H-benzimidazol-2-yl]piperazine; 4-(1-(5-Nitropyridin-2-yl)-1H-benzo[d]imidazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester; 1-(1,1-Dimethylethyl) 4-[1-(5-nitro-2-pyridinyl)-1H-benzimidazol-2-yl]-1-piperazinecarboxylate; 1146080-59-2; BOC-Piperazine-Benzimidazole-Nitropyridine Intermediate
EINECS	Contact for details

Quality Control

Every batch of 4-[1-(5-Nitro-Pyridin-2-Yl)-1H-Benzoimidazol-2-Yl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure a purity of 98+% and compliance with research and development specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.