Description

Methyl n-[(4-Chloro-1H-Indol-1-Yl)Acetyl]Glycinate is a high-purity synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a key building block in the development of novel pharmaceutical agents, particularly those targeting specific biological pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those with indole-based pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes within R&D laboratories.
• Process Chemistry: Serves as a defined intermediate in scale-up and route development for active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Potential utility in creating labeled compounds or probes for biochemical and diagnostic applications.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis projects.

Basic Information

Product Name	Methyl n-[(4-Chloro-1H-Indol-1-Yl)Acetyl]Glycinate
CAS No.	1144429-19-5
Molecular Formula	C13H11ClN2O3
Molecular Weight	278.69 g/mol
Synonyms	Methyl N-[(4-Chloro-1H-indol-1-yl)acetyl]glycinate; Glycine, N-[(4-chloro-1H-indol-1-yl)acetyl]-, methyl ester; Methyl 2-[[(4-chloro-1H-indol-1-yl)acetyl]amino]acetate; 1H-Indole-1-acetic acid, 4-chloro-, 2-(methoxycarbonyl)ethyl ester (related); 4-Chloro-1H-indole-1-acetic acid glycine methyl ester adduct
EINECS	Contact for details

Quality Control

Our Methyl n-[(4-Chloro-1H-Indol-1-Yl)Acetyl]Glycinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry, inert conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.