Description

4,6-Dichloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidine is a high-value, advanced pharmaceutical intermediate with the CAS registry number 1144080-31-8. This heterocyclic compound is specifically engineered to serve as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is essential for research and development chemists and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-purity intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other targeted therapeutic agents.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a critical starting material for scaling up API synthesis under cGMP conditions.
• Biochemical Research: Employed as a tool compound for studying enzymatic pathways and biological target interactions.
• Custom Synthesis: A foundational component for the contract manufacturing of specialized, high-potency APIs.

Basic Information

Product Name	4,6-Dichloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidine
CAS No.	1144080-31-8
Molecular Formula	C15H16Cl2N4O2
Molecular Weight	355.22 g/mol
Synonyms	1-(1,4-Dioxaspiro[4.5]decan-8-yl)-4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine; 4,6-Dichloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidine; 1H-Pyrazolo[3,4-d]pyrimidine, 4,6-dichloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-; 1144080-31-8; 4,6-Dichloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)pyrazolo[3,4-d]pyrimidine; Spirocyclic pyrazolopyrimidine intermediate; 1-(1,4-Dioxaspiro[4.5]decan-8-yl)-4,6-dichloro-pyrazolo[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to ISO 9001 standards, and the material is suitable for use in cGMP environments. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.