Description

Ixekizumab is a high-purity, recombinant humanized monoclonal antibody designed for targeted therapeutic intervention. This biologic agent is critical for its specific antagonism of interleukin-17A (IL-17A), a key cytokine involved in inflammatory pathways. It is primarily utilized by the pharmaceutical and biotechnology industries for the research, development, and manufacturing of advanced biologic treatments for chronic autoimmune conditions.

Application

• Active Pharmaceutical Ingredient (API) for the formulation of commercial biologic drugs.
• Clinical Research & Development for investigating new therapeutic applications and delivery mechanisms.
• Biosimilar Development as a reference standard for analytical characterization and comparability studies.
• Pre-clinical Studies to understand pharmacokinetics, pharmacodynamics, and mechanism of action.
• Process Development & Optimization in biomanufacturing for scale-up and purification.
• Quality Control & Analytical Reference for method validation and assay standardization.

Basic Information

Product Name	Ixekizumab
CAS No.	1143503-69-8
Molecular Formula	Contact for details
Molecular Weight	Approx. 146-148 kDa
Synonyms	LY2439821; Taltz® (brand name); Anti-IL-17A Monoclonal Antibody; Recombinant Humanized IgG4 Monoclonal Antibody to IL-17A; Immunoglobulin G4, anti-(human interleukin 17A) (human-mouse monoclonal LY2439821 γ4-chain), disulfide with human-mouse monoclonal LY2439821 light chain, dimer
EINECS	Contact for details

Quality Control

Our Ixekizumab is manufactured under strict quality management systems. Each batch is subjected to a comprehensive battery of analytical tests to ensure identity, purity, potency, and safety, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) providing specifications for purity (by SEC-HPLC and CE-SDS), bioactivity, endotoxin levels, and residual host cell proteins is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled atmospheric conditions where applicable. For in-use periods, follow appropriate cold chain (2-8°C) protocols.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear to slightly opalescent solution
Identification (SEC-HPLC / CE-SDS)	Conforms to reference standard
Purity (Monomer by SEC-HPLC)	≥ 98.0%
Purity (CE-SDS, Reduced & Non-reduced)	Conforms to reference standard
Potency (Cell-based Bioassay)	90% - 110% of reference standard
Protein Content (A280)	90% - 110% of label claim
Endotoxin	< 1.0 EU/mg
Host Cell Protein (HCP)	< 100 ppm
pH	5.5 - 6.5 (for solution)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.