Description

n-(5-(4-(Hydroxymethyl)Phenyl)-[1,2,4]Triazolo[1,5-A]Pyridin-2-Yl)Cyclopropanecarboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, especially within oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel, high-value active pharmaceutical ingredients (APIs).
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in research pipelines.
• Oncology Research: Serves as a core scaffold for developing potential kinase inhibitors and other targeted cancer therapies.
• CNS-Active Compound Synthesis: Employed in the research and development of potential therapeutics for neurological and psychiatric disorders.
• Chemical Biology: Utilized as a probe or tool compound for studying specific biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	n-(5-(4-(Hydroxymethyl)Phenyl)-[1,2,4]Triazolo[1,5-A]Pyridin-2-Yl)Cyclopropanecarboxamide
CAS No.	1142936-49-9
Molecular Formula	C18H16N4O2
Molecular Weight	320.35 g/mol
Synonyms	Cyclopropanecarboxamide, N-[5-[4-(hydroxymethyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-; 2-Cyclopropanecarboxamido-5-(4-hydroxymethylphenyl)-[1,2,4]triazolo[1,5-a]pyridine; CAS 1142936-49-9; [1,2,4]Triazolo[1,5-a]pyridine-2-carboxamide derivative; Hydroxymethylphenyl-triazolopyridine cyclopropanecarboxamide
EINECS	Contact for details

Quality Control

Our n-(5-(4-(Hydroxymethyl)Phenyl)-[1,2,4]Triazolo[1,5-A]Pyridin-2-Yl)Cyclopropanecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.