Description

2-Bromo-5-Cyclopropylpyridine is a high-value brominated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a bromine substituent and a cyclopropyl ring, makes it an essential intermediate for constructing complex molecules with specific steric and electronic properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the cyclopropyl moiety can enhance biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or conductive polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Biology Probes: Useful for creating tagged molecules or probes for studying biological pathways and protein interactions.

Basic Information

Product Name	2-Bromo-5-Cyclopropylpyridine
CAS No.	1142197-14-5
Molecular Formula	C8H8BrN
Molecular Weight	198.06 g/mol
Synonyms	5-Cyclopropyl-2-bromopyridine; 2-Bromo-5-cyclopropylpyridine; Pyridine, 2-bromo-5-cyclopropyl-; Bromo-cyclopropylpyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Cyclopropylpyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profile. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.