Description

3-Iodo-5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is engineered to serve as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated and fluorinated structure enables precise molecular modifications. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, anticancer agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides with enhanced efficacy and selectivity.
• Material Science: Serves as a building block for organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology: Employed as a probe or labeling agent in bioconjugation and target identification studies.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Fluorine Chemistry: The trifluoromethyl group is utilized to modulate lipophilicity, metabolic stability, and bioavailability in drug design.

Basic Information

Product Name	3-Iodo-5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	1142192-57-1
Molecular Formula	C8H4F3IN2
Molecular Weight	312.03 g/mol
Synonyms	3-Iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-iodo-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-3-iodo-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; CAS 1142192-57-1
EINECS	Contact for details

Quality Control

Our production of 3-Iodo-5-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials are characterized and released against comprehensive specifications, including identity confirmation by spectroscopic methods and purity determination by HPLC. Certificates of Analysis (COA) detailing all test results are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.