Description

tert-Butyl (6-Bromo-2-Chloropyridin-3-Yl)-Methylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a halogenated pyridine core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to construct complex molecules targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its reactive bromo and chloro substituents.
• Agrochemical Synthesis: Serves as a precursor in the development of new pesticides and herbicides, leveraging the pyridine scaffold.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and methodology development.

Basic Information

Product Name	tert-Butyl (6-Bromo-2-Chloropyridin-3-Yl)-Methylcarbamate
CAS No.	1142192-48-0
Molecular Formula	C11H14BrClN2O2
Molecular Weight	321.60 g/mol
Synonyms	tert-Butyl N-[(6-Bromo-2-chloropyridin-3-yl)methyl]carbamate; Carbamic acid, N-[(6-bromo-2-chloro-3-pyridinyl)methyl]-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl N-[(6-bromo-2-chloro-3-pyridinyl)methyl]carbamate; BOC-Protected 6-Bromo-2-chloro-3-(aminomethyl)pyridine; (6-Bromo-2-chloro-pyridin-3-ylmethyl)-carbamic acid tert-butyl ester; tert-Butyl (6-bromo-2-chloro-3-pyridylmethyl)carbamate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of tert-Butyl (6-Bromo-2-Chloropyridin-3-Yl)-Methylcarbamate is characterized and controlled using advanced analytical techniques such as HPLC, GC, NMR, and MS to confirm identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are available upon request. We support development under research-grade to cGMP standards as required for your project phase.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC / NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC Area %)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.