Description

tert-Butyl 2-Iodo-6-((Trimethylsilyl)ethynyl)-pyridin-3-yl carbonate is a highly functionalized pyridine derivative designed for advanced synthetic chemistry. This compound matters as a versatile and protected building block, offering orthogonal reactivity for the construction of complex molecular architectures. Pharmaceutical researchers and agrochemical developers need it for creating novel active ingredients, particularly in cross-coupling reactions and as a precursor to functionalized heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, especially those targeting kinases and other enzymes.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Serves as a precursor for functionalized ligands in catalysis and for creating advanced organic electronic materials.
• Cross-Coupling Reactions: The iodine and ethynyl groups make it an excellent substrate for Sonogashira, Suzuki-Miyaura, and other palladium-catalyzed couplings.
• Chemical Biology: Employed in the synthesis of molecular probes and tags for studying biological processes.
• Academic & R&D: A valuable reagent for methodological development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	tert-Butyl 2-Iodo-6-((Trimethylsilyl)ethynyl)-pyridin-3-yl carbonate
CAS No.	1142192-40-2
Molecular Formula	C15H20INO3Si
Molecular Weight	417.32 g/mol
Synonyms	tert-Butyl 2-iodo-6-((trimethylsilyl)ethynyl)pyridin-3-yl carbonate; 3-Pyridinol, 2-iodo-6-[(trimethylsilyl)ethynyl]-, 1,1-dimethylethyl carbonate; 2-Iodo-6-((trimethylsilyl)ethynyl)pyridin-3-yl tert-butyl carbonate; Carbonic acid, 2-iodo-6-[(trimethylsilyl)ethynyl]-3-pyridinyl tert-butyl ester; TBS-protected iodoethynyl pyridine carbonate; Boc-protected iodo-TMS-alkyne pyridine derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Iodo-6-((Trimethylsilyl)ethynyl)-pyridin-3-yl carbonate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.