Description

6-Bromo-5-Pivalamidonicotinic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific brominated nicotinic acid structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting neurological or metabolic pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes during drug discovery.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in multi-step synthetic routes for the manufacture of final APIs.
• Bioconjugation & Probe Development: Potential use in creating chemical probes or conjugates for biochemical and diagnostic applications due to its reactive bromine and carboxylic acid groups.
• Academic & Contract Research: Employed in academic research and by contract research organizations (CROs) for developing new synthetic methodologies.

Basic Information

Product Name	6-Bromo-5-Pivalamidonicotinic Acid
CAS No.	1142192-31-1
Molecular Formula	C11H13BrN2O3
Molecular Weight	301.14 g/mol
Synonyms	5-[(2,2-Dimethylpropanoyl)amino]-6-bromopyridine-3-carboxylic acid; 6-Bromo-5-pivalamidonicotinic acid; 6-Bromo-5-(pivalamido)nicotinic acid; 3-Pyridinecarboxylic acid, 6-bromo-5-[(2,2-dimethyl-1-oxopropyl)amino]-; 6-Bromo-5-(2,2-dimethylpropanamido)nicotinic acid
EINECS	Contact for details

Quality Control

Our 6-Bromo-5-Pivalamidonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and relevant industry guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.