Description

Methyl 3-(6-Bromo-2-Chloropyridin-3-Yl)Acrylate is a high-value, multi-functional chemical intermediate featuring a reactive acrylate ester group attached to a halogenated pyridine core. This compound is essential for facilitating advanced synthetic transformations, particularly in constructing complex molecular architectures for active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for its versatility in cross-coupling and cycloaddition reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced pesticides, herbicides, and fungicides due to its bioactive pyridine scaffold.
• Material Science Research: Serves as a monomer or precursor for functional polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed coupling reactions.
• Chemical Biology Probes: Utilized in the creation of tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	Methyl 3-(6-Bromo-2-Chloropyridin-3-Yl)Acrylate
CAS No.	1142192-22-0
Molecular Formula	C9H7BrClNO2
Molecular Weight	276.51 g/mol
Synonyms	Methyl (2E)-3-(6-Bromo-2-chloro-3-pyridinyl)-2-propenoate; (E)-Methyl 3-(6-bromo-2-chloropyridin-3-yl)acrylate; 2-Propenoic acid, 3-(6-bromo-2-chloro-3-pyridinyl)-, methyl ester, (2E)-; Methyl 3-(6-Bromo-2-Chloro-3-Pyridyl)Acrylate; 6-Bromo-2-chloropyridin-3-yl-acrylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 3-(6-Bromo-2-Chloropyridin-3-Yl)Acrylate is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.