Description

Methyl 3-(6-Chloro-5-Pivalamidopyridin-2-Yl)-Acrylate CAS NO 1142192-21-9 is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine-acrylate hybrid structure. This compound is of significant commercial value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of targeted small-molecule drugs, particularly in oncology and anti-inflammatory research pipelines.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation pesticides and herbicides, leveraging its heterocyclic core.
• Chemical Research & Development: Used in academic and industrial R&D for exploring new chemical entities and reaction pathways in medicinal chemistry.
• API Manufacturing: Employed in the scaled-up production of active pharmaceutical ingredients requiring its specific molecular framework.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized compounds for client projects.

Basic Information

Product Name	Methyl 3-(6-Chloro-5-Pivalamidopyridin-2-Yl)-Acrylate
CAS No.	1142192-21-9
Molecular Formula	C14H17ClN2O3
Molecular Weight	296.75 g/mol
Synonyms	Methyl (2E)-3-(6-Chloro-5-[(2,2-dimethylpropanoyl)amino]pyridin-2-yl)prop-2-enoate; (E)-Methyl 3-(6-chloro-5-pivalamidopyridin-2-yl)acrylate; 2-Propenoic acid, 3-(6-chloro-5-[(2,2-dimethyl-1-oxopropyl)amino]-2-pyridinyl)-, methyl ester, (2E)-; Methyl 3-(6-Chloro-5-pivalamido-2-pyridyl)acrylate; 1142192-21-9; Pivalamido Pyridine Acrylate Ester
EINECS	Contact for details

Quality Control

Our Methyl 3-(6-Chloro-5-Pivalamidopyridin-2-Yl)-Acrylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.