Description

n-(2-Chloro-6-(3-Hydroxyprop-1-Ynyl)Pyridin-3-Yl)-Pivalamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine-based structure with chloro and hydroxypropynyl substituents. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in research and development for targeted therapies. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in oncology and neurological disorder research.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides due to its bioactive pyridine core.
• Organic Synthesis Reagent: Serves as a versatile precursor for constructing complex molecular architectures in academic and industrial research.
• Ligand and Catalyst Development: Employed in the design of specialized ligands for metal-catalyzed cross-coupling reactions.
• Material Science Research: Investigated as a monomer or additive for creating functional polymers with specific electronic properties.
• Bioconjugation Chemistry: Utilized in the development of probe molecules and targeted drug delivery systems.

Basic Information

Product Name	n-(2-Chloro-6-(3-Hydroxyprop-1-Ynyl)Pyridin-3-Yl)-Pivalamide
CAS No.	1142192-04-8
Molecular Formula	C13H15ClN2O2
Molecular Weight	266.72 g/mol
Synonyms	Pivalamide, N-[2-chloro-6-(3-hydroxy-1-propyn-1-yl)-3-pyridinyl]-; 2-Chloro-6-(3-hydroxyprop-1-yn-1-yl)-N-(2,2-dimethylpropanoyl)pyridin-3-amine; 1142192-04-8; Tert-butylamide derivative of chlorohydroxypropynylpyridine; 3-Pyridinamine, 2-chloro-6-(3-hydroxy-1-propyn-1-yl)-N-(2,2-dimethyl-1-oxopropyl)-; N-(2-Chloro-6-(3-hydroxyprop-1-ynyl)pyridin-3-yl)-2,2-dimethylpropanamide
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-6-(3-Hydroxyprop-1-Ynyl)Pyridin-3-Yl)-Pivalamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and hygroscopic; therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.