Description

Methyl 6-Bromo-2-Chloronicotinate is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce halogenated pyridine motifs into their target structures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require halogenated nicotinate scaffolds.
• Material Science Research: Serves as a building block for creating functionalized ligands, organic semiconductors, and photoactive materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the reactive bromo and chloro substituents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.
• Academic & Institutional Research: Utilized in university and institutional labs for methodological development and exploring new chemical spaces.

Basic Information

Product Name	Methyl 6-Bromo-2-Chloronicotinate
CAS No.	1142192-03-7
Molecular Formula	C7H5BrClNO2
Molecular Weight	250.48 g/mol
Synonyms	Methyl 6-bromo-2-chloropyridine-3-carboxylate; 2-Chloro-6-bromonicotinic acid methyl ester; 6-Bromo-2-chloro-3-pyridinecarboxylic acid methyl ester; Methyl 2-chloro-6-bromonicotinate; 3-Pyridinecarboxylic acid, 6-bromo-2-chloro-, methyl ester; 6-Bromo-2-chloronicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 6-Bromo-2-Chloronicotinate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.