Description

6-Bromo-2-Chloro-3-(Trimethylsilyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and a trimethylsilyl protecting group, makes it indispensable for constructing complex molecular architectures with precise regiochemistry. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the reactive bromine substituent.
• Directed Metalation: The trimethylsilyl group acts as a powerful directing metalation group (DMG), enabling selective functionalization at specific positions on the pyridine ring.
• Chemical Research: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	6-Bromo-2-Chloro-3-(Trimethylsilyl)Pyridine
CAS No.	1142191-85-2
Molecular Formula	C9H13BrClNSi
Molecular Weight	294.65 g/mol
Synonyms	3-Bromo-6-Chloro-2-(Trimethylsilyl)Pyridine; 2-Chloro-6-Bromo-3-(Trimethylsilyl)Pyridine; 2-Chloro-3-Trimethylsilyl-6-Bromopyridine; 6-Bromo-2-Chloro-3-(TMS)Pyridine; Pyridine, 6-bromo-2-chloro-3-(trimethylsilyl)-; TMS-Protected Bromochloropyridine; Bromochlorotrimethylsilylpyridine
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Chloro-3-(Trimethylsilyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.