Description

n-(2-Chloro-6-(Trimethylsilyl)Pyridin-3-Yl)-Pivalamide is a high-value, organosilicon-substituted pyridine derivative used as a key synthetic intermediate in advanced organic chemistry. This compound matters for its role in constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting various disease areas.
• Agrochemical Synthesis: Used in the research and development of new active ingredients for crop protection products, leveraging its unique halogen and silyl functional groups.
• Ligand Precursor: Serves as a starting material for the preparation of specialized ligands used in catalysis and metal-organic chemistry.
• Material Science Research: Employed in the development of advanced organic materials, including organic semiconductors and liquid crystals.
• Cross-Coupling Reactions: The chloro and trimethylsilyl groups make it a valuable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Stille, Suzuki).
• Chemical Biology Probes: Utilized in the design and synthesis of chemical probes for studying biological systems and target identification.

Basic Information

Product Name	n-(2-Chloro-6-(Trimethylsilyl)Pyridin-3-Yl)-Pivalamide
CAS No.	1142191-74-9
Molecular Formula	C13H21ClN2OSi
Molecular Weight	284.86 g/mol
Synonyms	2-Chloro-6-(trimethylsilyl)-N-(2,2-dimethylpropanoyl)pyridin-3-amine; Pivalamide, N-[2-chloro-6-(trimethylsilyl)-3-pyridinyl]-; N-(2-Chloro-6-(trimethylsilyl)pyridin-3-yl)-2,2-dimethylpropanamide; 3-Pivalamido-2-chloro-6-trimethylsilylpyridine; 1142191-74-9; Tert-butylcarboxamide derivative of 3-amino-2-chloro-6-trimethylsilylpyridine
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-6-(Trimethylsilyl)Pyridin-3-Yl)-Pivalamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) with full analytical data are provided for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.