Description

Methyl 3-(2-Chloro-4-Iodopyridin-3-Yl)Acrylate CAS NO 1142191-73-8 is a high-value halogenated pyridine derivative, specifically engineered as a versatile building block for advanced organic synthesis. Its unique structure, featuring both chloro and iodo substituents on the pyridine ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a monomer or functionalizing agent for creating specialty polymers and liquid crystals with specific optical or electronic properties.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes.
• Organic Light-Emitting Diodes (OLEDs): Investigated as a building block for electron-transport materials or emissive layer components in OLED devices.

Basic Information

Product Name	Methyl 3-(2-Chloro-4-Iodopyridin-3-Yl)Acrylate
CAS No.	1142191-73-8
Molecular Formula	C9H7ClINO2
Molecular Weight	323.52 g/mol
Synonyms	Methyl (2E)-3-(2-Chloro-4-iodo-3-pyridinyl)-2-propenoate; (E)-Methyl 3-(2-chloro-4-iodopyridin-3-yl)acrylate; 2-Propenoic acid, 3-(2-chloro-4-iodo-3-pyridinyl)-, methyl ester, (2E)-; Methyl 3-(2-chloro-4-iodopyridin-3-yl)acrylate; 3-Pyridineacrylic acid, 2-chloro-4-iodo-, methyl ester; Methyl trans-3-(2-chloro-4-iodopyridin-3-yl)acrylate
EINECS	Contact for details

Quality Control

Our Methyl 3-(2-Chloro-4-Iodopyridin-3-Yl)Acrylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support development work from discovery through to pre-clinical stages, with specifications that can be aligned with current Good Manufacturing Practice (cGMP) principles for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.