Description

4-Methoxy-3-((Trimethylsilyl)Ethynyl)Pyridin-2-Amine is a high-purity, functionalized pyridine derivative featuring a trimethylsilyl-protected alkyne group, making it a versatile and valuable building block in advanced organic synthesis. This compound is specifically engineered for applications requiring precise molecular architecture and controlled reactivity. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex heterocyclic scaffolds found in drug candidates, particularly in kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific pyridine-based structures.
• Material Science Research: Serves as a precursor for functionalized polymers or organic electronic materials due to its conjugated alkyne system.
• Cross-Coupling Reactions: The protected alkyne moiety is ideal for Sonogashira and other palladium-catalyzed cross-coupling reactions to create extended conjugated systems.
• Ligand Synthesis: Employed in the development of novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological processes via click chemistry after deprotection.

Basic Information

Product Name	4-Methoxy-3-((Trimethylsilyl)Ethynyl)Pyridin-2-Amine
CAS No.	1142191-65-8
Molecular Formula	C11H18N2OSi
Molecular Weight	222.36 g/mol
Synonyms	2-Amino-4-methoxy-3-[(trimethylsilyl)ethynyl]pyridine; 3-Ethynyl-4-methoxypyridin-2-amine, trimethylsilyl derivative; 4-Methoxy-3-(2-trimethylsilylethynyl)pyridin-2-amine; 2-Pyridinamine, 4-methoxy-3-[(trimethylsilyl)ethynyl]-; TMS-Protected 3-Ethynyl-4-methoxy-2-aminopyridine
EINECS	Contact for details

Quality Control

Our production of 4-Methoxy-3-((Trimethylsilyl)Ethynyl)Pyridin-2-Amine adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture uptake, which may affect stability and reactivity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.