Description

5-Bromo-2-Chloro-4-Methyl-Nicotinonitrile is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because it serves as a critical precursor for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific halogenated and nitrile-substituted pyridine motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the pyridine core is a common bioactive scaffold.
• Material Science: Serves as a building block for creating functionalized ligands in coordination chemistry and for synthesizing specialized polymers.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for biological target validation.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Library Synthesis: A valuable starting material for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Product Name	5-Bromo-2-Chloro-4-Methyl-Nicotinonitrile
CAS No.	1142188-71-3
Molecular Formula	C7H4BrClN2
Molecular Weight	231.48 g/mol
Synonyms	5-Bromo-2-chloro-4-methylpyridine-3-carbonitrile; 3-Cyano-5-bromo-2-chloro-4-methylpyridine; 2-Chloro-5-bromo-4-methyl-3-pyridinecarbonitrile; 4-Methyl-5-bromo-2-chloro-3-cyanopyridine; 5-Bromo-2-chloro-4-methyl-3-cyanopyridine; 2-Chloro-4-methyl-5-bromonicotinonitrile; Nicotinonitrile, 5-bromo-2-chloro-4-methyl-
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Chloro-4-Methyl-Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.