Description

(S)-tert-Butyl 3-(5-Aminopyridin-2-Yloxy)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and Boc-protected intermediate of significant value in modern synthetic chemistry. Its primary importance lies in providing a stereochemically defined scaffold for the efficient construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical building block in the research and scale-up synthesis of proprietary APIs.
• Asymmetric Synthesis: Utilized in the construction of complex, enantiomerically pure molecules due to its defined (S)-configuration at the pyrrolidine center.
• Peptidomimetics & Bioisosteres: The aminopyridyloxy moiety makes it valuable for creating non-peptide analogs and bioisosteric replacements in drug design.
• Chemical Biology Probe Synthesis: Used to develop tool compounds and molecular probes for target validation and mechanistic studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical and biotech companies in their discovery and development pipelines.

Basic Information

Product Name	(S)-tert-Butyl 3-(5-Aminopyridin-2-Yloxy)Pyrrolidine-1-Carboxylate
CAS No.	1141488-38-1
Molecular Formula	C14H21N3O3
Molecular Weight	279.34 g/mol
Synonyms	1-Boc-3-((5-amino-2-pyridyl)oxy)-(S)-pyrrolidine; (S)-1-(tert-Butoxycarbonyl)-3-[(5-amino-2-pyridinyl)oxy]pyrrolidine; tert-Butyl (3S)-3-[(5-aminopyridin-2-yl)oxy]pyrrolidine-1-carboxylate; (S)-N-Boc-3-(5-amino-2-pyridyloxy)pyrrolidine; (S)-tert-Butyl 3-((5-aminopyridin-2-yl)oxy)pyrrolidine-1-carboxylate; 1-Pyrrolidinecarboxylic acid, 3-[(5-amino-2-pyridinyl)oxy]-, 1,1-dimethylethyl ester, (3S)-; Boc-(S)-3-(5-Amino-pyridin-2-yloxy)-pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-tert-Butyl 3-(5-Aminopyridin-2-Yloxy)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, chiral HPLC, 1H/13C NMR, and mass spectrometry, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.