Description

tert-Butyl (4-Hydroxy-5-Methoxypyridin-3-Yl)-Methylcarbamate CAS NO 1138444-22-0 is a sophisticated pyridine derivative carbamate, serving as a critical protected intermediate in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of functionalized pyridine moieties into complex molecular architectures, a key step in pharmaceutical and agrochemical research. This compound is essential for R&D chemists and process development scientists working on novel active ingredients, particularly in the synthesis of drug candidates and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the pyridine core offers unique biological activity.
• Chemical Biology & Proteomics: Employed as a specialty reagent for designing enzyme inhibitors, activity-based probes, and molecular tags due to its reactive carbamate and hydroxyl groups.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, ligands for catalysis, and advanced organic materials.
• Academic & Contract Research: A valuable tool for methodology development and exploratory synthesis in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	tert-Butyl (4-Hydroxy-5-Methoxypyridin-3-Yl)-Methylcarbamate
CAS No.	1138444-22-0
Molecular Formula	C12H18N2O4
Molecular Weight	254.28 g/mol
Synonyms	tert-Butyl N-[(4-hydroxy-5-methoxypyridin-3-yl)methyl]carbamate; 3-[[(tert-Butoxycarbonyl)amino]methyl]-5-methoxypyridin-4-ol; Carbamic acid, N-[(4-hydroxy-5-methoxy-3-pyridinyl)methyl]-, 1,1-dimethylethyl ester; (4-Hydroxy-5-methoxypyridin-3-yl)methylcarbamic acid tert-butyl ester; BOC-protected 3-(aminomethyl)-5-methoxy-4-hydroxypyridine; tert-Butyl (4-hydroxy-5-methoxy-3-pyridylmethyl)carbamate
EINECS	Contact for details

Quality Control

Our production of tert-Butyl (4-Hydroxy-5-Methoxypyridin-3-Yl)-Methylcarbamate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture absorption. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.