Description

tert-Butyl 3-Cyano-5-Methoxypyridin-4-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core with cyano and carbamate protecting groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex active pharmaceutical ingredients (APIs) with high selectivity and yield. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of potent drug candidates and investigational new drugs (INDs).
• API Development: Serves as a crucial precursor in constructing the core scaffold for target molecules in oncology and neurological research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in academic and industrial R&D labs.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CRAMOs) for bespoke, gram-to-kilogram scale production under cGMP guidelines.
• Chemical Biology: Utilized as a probe or labeled compound in biochemical assays and mechanism-of-action studies.

Basic Information

Product Name	tert-Butyl 3-Cyano-5-Methoxypyridin-4-Ylcarbamate
CAS No.	1138444-19-5
Molecular Formula	C12H15N3O3
Molecular Weight	249.27 g/mol
Synonyms	4-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-methoxy-3-pyridinecarbonitrile; tert-Butyl N-(3-cyano-5-methoxy-4-pyridyl)carbamate; 4-(tert-Butoxycarbonylamino)-5-methoxynicotinonitrile; Boc-Protected 3-Cyano-5-Methoxy-4-Aminopyridine; 4-Amino-5-methoxynicotinonitrile tert-butylcarbamate; 3-Cyano-5-methoxy-4-pyridinylcarbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 3-Cyano-5-Methoxypyridin-4-Ylcarbamate adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements, supporting development under quality-by-design (QbD) principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.