Description

tert-Butyl 3-Hydroxy-5-Methoxyisonicotinate is a high-purity pyridine derivative ester, serving as a critical pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in its functionalized isonicotinate core, which is essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides due to its bioactive pyridine scaffold.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry and for contract research organizations (CROs) supporting drug discovery programs.
• Material Science Research: Potential monomer or modifier in the development of functional polymers and advanced organic materials.

Basic Information

Product Name	tert-Butyl 3-Hydroxy-5-Methoxyisonicotinate
CAS No.	1138444-13-9
Molecular Formula	C11H15NO4
Molecular Weight	225.24 g/mol
Synonyms	5-Methoxy-3-hydroxypyridine-4-carboxylic acid tert-butyl ester; tert-Butyl 5-methoxy-3-oxo-1,4-dihydropyridine-4-carboxylate; 3-Hydroxy-5-methoxyisonicotinic acid tert-butyl ester; 4-Carboxy-5-methoxy-3-hydroxypyridine tert-butyl ester; TB 3-Hydroxy-5-Methoxyisonicotinate
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Hydroxy-5-Methoxyisonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete batch data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.