Description

2-Chloro-3-((Trimethylsilyl)Ethynyl)Pyridin-4-Amine is a specialized pyridine derivative featuring both a chloro substituent and a trimethylsilyl-protected ethynyl group, making it a versatile and valuable advanced pharmaceutical intermediate for modern synthetic chemistry. Its molecular architecture is specifically designed to serve as a key building block in the synthesis of complex, biologically active molecules. This compound is primarily utilized by research institutions and pharmaceutical R&D departments engaged in developing new therapeutic agents, particularly in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially for targeted therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its functionalized pyridine core.
• Material Science: Serves as a monomer or cross-linking agent in the creation of specialty polymers and advanced organic materials.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create molecular probes for studying biological pathways and enzyme functions.
• Academic & Industrial R&D: Fundamental building block for exploratory chemistry in both university laboratories and corporate research centers.

Basic Information

Product Name	2-Chloro-3-((Trimethylsilyl)Ethynyl)Pyridin-4-Amine
CAS No.	1138444-10-6
Molecular Formula	C10H13ClN2Si
Molecular Weight	224.76 g/mol
Synonyms	4-Amino-2-chloro-3-[(trimethylsilyl)ethynyl]pyridine; 2-Chloro-3-((trimethylsilyl)ethynyl)-4-pyridinamine; 2-Chloro-3-[(trimethylsilyl)ethynyl]pyridin-4-amine; 4-Pyridinamine, 2-chloro-3-[(trimethylsilyl)ethynyl]-; 1138444-10-6; TMS-protected ethynyl pyridine amine; Chloro(trimethylsilylethynyl)aminopyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-((Trimethylsilyl)Ethynyl)Pyridin-4-Amine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with exacting research and development standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.