Description

2-Chloro-4-Iodo-3-(Trimethylsilyl)Pyridine is a high-value, multi-functional halogenated organosilicon building block. This compound matters for its unique reactivity profile, offering distinct sites for cross-coupling and functional group transformations, which is critical for constructing complex molecular architectures. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, leveraging its halogen and silyl groups for selective coupling reactions.
• Material Science Research: Serves as a precursor for functionalized pyridine derivatives used in organic electronic materials and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl systems.
• Ligand Synthesis: Utilized for the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Chemical Biology Probes: Acts as a building block for synthesizing labeled compounds or probes for biochemical and diagnostic applications.

Basic Information

Item	Detail
Product Name	2-Chloro-4-Iodo-3-(Trimethylsilyl)Pyridine
CAS No.	1138444-01-5
Molecular Formula	C8H11ClINSi
Molecular Weight	311.62 g/mol
Synonyms	3-(Trimethylsilyl)-2-chloro-4-iodopyridine; 2-Chloro-4-iodo-3-(trimethylsilyl)pyridine; 2-Chloro-4-iodo-3-trimethylsilylpyridine; Pyridine, 2-chloro-4-iodo-3-(trimethylsilyl)-; 1138444-01-5; 2-Chloro-4-iodo-3-TMS-pyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Iodo-3-(Trimethylsilyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.