Description

Methyl 3-(5-Bromo-3-Methoxypyridin-2-Yl)Acrylate is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is valued for its functionalized pyridine-acrylate structure, which is crucial for constructing complex molecules in medicinal chemistry. It is primarily used by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its halogenated heterocyclic structure.
• Material Science: Serves as a monomer or precursor for functional polymers and advanced organic electronic materials.
• Chemical Synthesis: Versatile reagent for Suzuki-Miyaura and other cross-coupling reactions due to the presence of the bromine substituent.
• Academic & R&D: Essential compound for methodological studies in organic chemistry and medicinal chemistry research programs.
• Ligand Synthesis: Precursor for creating complex chelating ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Methyl 3-(5-Bromo-3-Methoxypyridin-2-Yl)Acrylate
CAS No.	1138443-99-8
Molecular Formula	C10H10BrNO3
Molecular Weight	272.10 g/mol
Synonyms	Methyl (2E)-3-(5-Bromo-3-methoxypyridin-2-yl)prop-2-enoate; (E)-Methyl 3-(5-bromo-3-methoxypyridin-2-yl)acrylate; 2-Propenoic acid, 3-(5-bromo-3-methoxy-2-pyridinyl)-, methyl ester, (2E)-; Methyl (E)-3-(5-bromo-3-methoxypyridin-2-yl)acrylate; 5-Bromo-3-methoxy-2-pyridineacrylic acid methyl ester; Methyl 3-(5-bromo-3-methoxy-2-pyridinyl)-2-propenoate
EINECS	Contact for details

Quality Control

Our Methyl 3-(5-Bromo-3-Methoxypyridin-2-Yl)Acrylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.