Description

5-Bromo-2-((tert-Butyldimethylsilyloxy)Methyl)-3-Methoxypyridine CAS NO 1138443-85-2 is a high-value, protected pyridine derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its primary commercial value lies in its role as a versatile building block for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity intermediates for constructing active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides, herbicides, and fungicides where the pyridine moiety is a core structural feature.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as components for OLEDs or conductive polymers.
• Chemical Biology Probes: Utilized to create tagged or modified molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	5-Bromo-2-((tert-Butyldimethylsilyloxy)Methyl)-3-Methoxypyridine
CAS No.	1138443-85-2
Molecular Formula	C13H22BrNO2Si
Molecular Weight	332.31 g/mol
Synonyms	5-Bromo-2-(((tert-butyldimethylsilyl)oxy)methyl)-3-methoxypyridine; 3-Methoxy-5-bromo-2-(((tert-butyldimethylsilyl)oxy)methyl)pyridine; 2-((tert-Butyldimethylsilyloxy)methyl)-5-bromo-3-methoxypyridine; 5-Bromo-3-methoxy-2-(((tert-butyldimethylsilyl)oxy)methyl)pyridine; TBS-protected 5-bromo-2-(hydroxymethyl)-3-methoxypyridine; 5-Bromo-2-((TBDMS-oxy)methyl)-3-methoxypyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-((tert-Butyldimethylsilyloxy)Methyl)-3-Methoxypyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC, GC, NMR, and MS, are validated to provide reliable data. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be sensitive to fluoride/strong alkali. Keep the container tightly sealed to protect from moisture and atmospheric contamination. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.