Description

5-(Piperidin-4-Yl)Nicotinonitrile Dihydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a strategically functionalized heterocyclic scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery programs targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent and selective kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Biochemical Tool Compound: Serves as a reference standard or a starting material for developing biochemical probes and assay reagents.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical candidates.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and novel synthetic methodologies.

Basic Information

Product Name	5-(Piperidin-4-Yl)Nicotinonitrile Dihydrochloride
CAS No.	1137949-73-5
Molecular Formula	C11H14N4 · 2HCl
Molecular Weight	283.18 g/mol (Free base: 202.26)
Synonyms	5-(4-Piperidinyl)-3-pyridinecarbonitrile dihydrochloride; Nicotinonitrile, 5-(4-piperidinyl)-, dihydrochloride; 5-(Piperidin-4-yl)pyridine-3-carbonitrile dihydrochloride; 3-Cyano-5-(4-piperidinyl)pyridine dihydrochloride
EINECS	Contact for details

Quality Control

Our 5-(Piperidin-4-Yl)Nicotinonitrile Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.