Description

2-Amino-2-(5-Bromopyridin-3-Yl)Acetic Acid Hydrochloride is a high-purity, non-natural amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in its unique pyridine-bromine scaffold and amino acid functionality, enabling the construction of complex, pharmaceutically relevant molecules with precise stereochemistry. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the design and synthesis of novel, high-performance pesticides and herbicides, leveraging its halogenated heterocyclic structure.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Incorporated into peptide analogs to enhance stability, bioavailability, and target binding affinity in medicinal chemistry projects.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity chiral intermediates.

Basic Information

Product Name	2-Amino-2-(5-Bromopyridin-3-Yl)Acetic Acid Hydrochloride
CAS No.	1135916-90-3
Molecular Formula	C7H8BrN2O2•HCl
Molecular Weight	281.52 g/mol (Free base: 245.06 g/mol)
Synonyms	(5-Bromo-3-pyridinyl)glycine hydrochloride; 2-Amino-2-(5-bromo-3-pyridinyl)acetic acid hydrochloride; 5-Bromo-3-pyridylglycine HCl; 2-Azanyl-2-(5-bromopyridin-3-yl)acetic acid;hydrochloride; (5-Bromopyridin-3-yl)glycine hydrochloride; α-Amino-(5-bromo-3-pyridyl)acetic acid hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-2-(5-Bromopyridin-3-Yl)Acetic Acid Hydrochloride is manufactured under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and chiral integrity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.