Description

Methyl (2E)-(7-Methyl-3-Oxo-3,4-Dihydro-2H-1,4-Benzoxazin-2-Ylidene)Acetate is a high-purity, advanced pharmaceutical intermediate characterized by its benzoxazinone core structure. This compound is valued for its role as a key synthetic building block in the development of novel active pharmaceutical ingredients (APIs), particularly in research targeting complex heterocyclic systems. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for synthesis and scale-up projects. The product, CAS No. 1135585-72-6, is supplied with full analytical documentation to ensure traceability and support critical development workflows.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of complex drug candidates, especially those containing benzoxazinone or related fused heterocyclic scaffolds.
• Agrochemical Research: Used in the development of new herbicides and fungicides where the benzoxazinone moiety can impart specific biological activity.
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex molecular architectures via reactions at its reactive ester and olefinic sites.
• Material Science Precursor: Investigated for the synthesis of organic electronic materials and specialty polymers requiring specific photophysical properties.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	Methyl (2E)-(7-Methyl-3-Oxo-3,4-Dihydro-2H-1,4-Benzoxazin-2-Ylidene)Acetate
CAS No.	1135585-72-6
Molecular Formula	C₁₃H₁₃NO₄
Molecular Weight	247.25 g/mol
Synonyms	(2E)-2-(7-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-ylidene)acetic acid methyl ester; Methyl 2-(7-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-ylidene)acetate; (E)-Methyl 2-(7-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-ylidene)acetate; 2H-1,4-Benzoxazin-2-ylideneacetic acid, 3,4-dihydro-7-methyl-3-oxo-, methyl ester, (2E)-; Methyl (E)-2-(7-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-ylidene)acetate
EINECS	Contact for details

Quality Control

Our Methyl (2E)-(7-Methyl-3-Oxo-3,4-Dihydro-2H-1,4-Benzoxazin-2-Ylidene)Acetate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all test results are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.