Description

2-[4-(tert-Butoxycarbonyl)Piperazino]-3-Chloroisonicotinic Acid is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core protected by a tert-butoxycarbonyl (Boc) group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially kinase inhibitors.
• Organic Synthesis: Used in medicinal chemistry for the construction of complex heterocyclic molecules containing functionalized piperazine and pyridine moieties.
• Research & Development: Serves as a crucial reagent in academic and industrial R&D labs for exploring new chemical entities and biological pathways.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and bespoke molecular scaffolds.

Basic Information

Product Name	2-[4-(tert-Butoxycarbonyl)Piperazino]-3-Chloroisonicotinic Acid
CAS No.	1135283-34-9
Molecular Formula	C15H20ClN3O4
Molecular Weight	341.79 g/mol
Synonyms	3-Chloro-2-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]pyridine-4-carboxylic acid; 2-(4-Boc-piperazino)-3-chloroisonicotinic acid; 3-Chloro-2-(4-Boc-piperazinyl)isonicotinic acid; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-3-chloropyridine-4-carboxylic acid; Boc-3-chloro-isonicotinic acid piperazine derivative; 1135283-34-9
EINECS	Contact for details

Quality Control

Our 2-[4-(tert-Butoxycarbonyl)Piperazino]-3-Chloroisonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to GMP-grade standards ensures the material is suitable for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.