Description

5-Chloro-6-Cyclopropyl-1-Methyl-1H-Pyrazolo[3,4-B]Pyridin-3-Amine is a high-purity, advanced pharmaceutical intermediate with significant value in modern drug discovery and development. This compound serves as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is essential for research and production teams in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new compounds with enhanced biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in kinase inhibitor research and development.
• Agrochemical Research: Used in the discovery and formulation of new-generation pesticides and herbicides, leveraging its heterocyclic structure.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study biological pathways and protein functions.
• Material Science: Investigated as a building block for organic electronic materials and specialty polymers due to its fused pyrazolopyridine core.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry programs and novel synthetic methodology development.

Basic Information

Product Name	5-Chloro-6-Cyclopropyl-1-Methyl-1H-Pyrazolo[3,4-B]Pyridin-3-Amine
CAS No.	1135283-21-4
Molecular Formula	C10H11ClN4
Molecular Weight	222.68 g/mol
Synonyms	5-Chloro-6-cyclopropyl-1-methyl-1H-pyrazolo[3,4-b]pyridin-3-amine; 1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-chloro-6-cyclopropyl-1-methyl-; 1135283-21-4; 5-Chloro-6-cyclopropyl-1-methyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine; 5-Chloro-6-cyclopropyl-1-methyl-pyrazolo[3,4-b]pyridin-3-amine
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-Cyclopropyl-1-Methyl-1H-Pyrazolo[3,4-B]Pyridin-3-Amine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the material meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.