Description

3-Chloro-2-Ethynyl-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional pyridine derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique molecular architecture, featuring both a reactive ethynyl group and a chloro-trifluoromethyl substituted pyridine ring, makes it indispensable for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine and trifluoromethyl motifs.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and organic electronic materials due to its ethynyl functionality.
• Chemical Biology Probe Development: Employed in creating tagged molecules and activity-based probes for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The chloro and ethynyl groups make it a versatile substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl and conjugated systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global R&D pipelines.

Basic Information

Product Name	3-Chloro-2-Ethynyl-5-(Trifluoromethyl)Pyridine
CAS No.	1135283-18-9
Molecular Formula	C8H3ClF3N
Molecular Weight	205.56 g/mol
Synonyms	2-Ethynyl-3-chloro-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-3-chloro-2-ethynylpyridine; 3-Chloro-2-ethynyl-5-trifluoromethylpyridine; Pyridine, 3-chloro-2-ethynyl-5-(trifluoromethyl)-; 1135283-18-9; 3-Chloro-2-ethynyl-α,α,α-trifluoro-5-pyridinemethanol (precursor name); 2-Ethynyl-3-chloro-5-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-Ethynyl-5-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality ensures the material meets the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.