Description

2,5-Dichloro-6-Cyclopropylnicotinonitrile is a high-value, multi-functional chemical intermediate characterized by its distinct pyridine core substituted with chloro, cyclopropyl, and nitrile groups. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the pyridine and cyclopropyl motifs.
• Material Science Research: Serves as a precursor for functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the synthesis of tool compounds and probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	2,5-Dichloro-6-Cyclopropylnicotinonitrile
CAS No.	1135283-17-8
Molecular Formula	C9H6Cl2N2
Molecular Weight	213.06 g/mol
Synonyms	6-Cyclopropyl-2,5-dichloronicotinonitrile; 2,5-Dichloro-6-cyclopropyl-3-pyridinecarbonitrile; 3-Pyridinecarbonitrile, 2,5-dichloro-6-cyclopropyl-; 2,5-Dichloro-6-cyclopropylpyridine-3-carbonitrile; 1135283-17-8
EINECS	Contact for details

Quality Control

Our 2,5-Dichloro-6-Cyclopropylnicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.