Description

3-Methyl-4-Oxo-4,7-Dihydroisothiazolo[5,4-B]Pyridine-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate with the CAS number 1134188-33-2. This heterocyclic carboxylic acid is a critical building block in modern medicinal chemistry, valued for its unique fused-ring structure that enables the synthesis of novel bioactive compounds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and anti-infective drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Oncology Drug Development: Used in the research and synthesis of potential kinase inhibitors and other targeted cancer therapies.
• Anti-infective Agent Synthesis: Employed as a building block for developing new antibacterial or antiviral compounds.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological processes and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical R&D and scale-up activities.

Basic Information

Product Name	3-Methyl-4-Oxo-4,7-Dihydroisothiazolo[5,4-B]Pyridine-5-Carboxylic Acid
CAS No.	1134188-33-2
Molecular Formula	C9H6N2O3S
Molecular Weight	222.22 g/mol
Synonyms	3-Methyl-4-oxo-4,7-dihydro-[1,2]thiazolo[5,4-b]pyridine-5-carboxylic acid; 3-Methyl-4-oxo-4H,7H-isothiazolo[5,4-b]pyridine-5-carboxylic acid; 1134188-33-2; Isothiazolo[5,4-b]pyridine-5-carboxylic acid, 4,7-dihydro-3-methyl-4-oxo-; 3-Methyl-4-oxo-4,7-dihydroisothiazolo[5,4-b]pyridine-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Methyl-4-Oxo-4,7-Dihydroisothiazolo[5,4-B]Pyridine-5-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.