Description

tert-Butyl 5,6-Dihydro-4-(5-Hydroxypyridin-2-Yl)Pyridine-1(2H)-Carboxylate CAS NO 1134112-71-2 is a high-purity, advanced pharmaceutical intermediate featuring a complex bicyclic structure with a protected amine and a hydroxypyridine moiety. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel therapeutic agents. It is primarily sought by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the production route for Active Pharmaceutical Ingredients (APIs) requiring a dihydropyridine or functionalized pyridine core structure.
• Chemical Biology Probes: Serves as a starting material for developing molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 5,6-Dihydro-4-(5-Hydroxypyridin-2-Yl)Pyridine-1(2H)-Carboxylate
CAS No.	1134112-71-2
Molecular Formula	C15H20N2O3
Molecular Weight	276.33 g/mol
Synonyms	tert-Butyl 4-(5-hydroxypyridin-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate; 1-Boc-4-(5-hydroxy-2-pyridyl)-1,2,3,6-tetrahydropyridine; 1,2,3,6-Tetrahydropyridine-1-carboxylic acid, 4-(5-hydroxy-2-pyridinyl)-, 1,1-dimethylethyl ester; 4-(5-Hydroxypyridin-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butyl ester; 1-N-Boc-4-(5-hydroxy-2-pyridyl)-1,2,3,6-tetrahydropyridine; Boc-4-(5-OH-Pyridin-2-yl)-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 5,6-Dihydro-4-(5-Hydroxypyridin-2-Yl)Pyridine-1(2H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements, including research-grade and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.